Endocrine Abstracts

Introduction: Lenvatinib is a multitarget tyrosine kinase inhibitor that has shown substantial efficacy in patients with progressive radioiodine refractory thyroid cancer (RAIRDTC) (progression free survival (PFS) 19.4 months and objective response rate 64.8%; SELECT trial) despite common adverse events (AEs).Objective: To evaluate efficacy and toxicity of lenvatinib treatment for RAIRDTC in daily clinical practice.Methods: Retrosp...

Background: Acute intermittent porphyria (AIP) is an inherited autosomal dominant disorder characterized by hepatic deficiency of hydroxymethylbilane synthase (HMBS)/porphobilinogen deaminase (PBGD), the third enzyme of the heme synthesis pathway. Hyponatremia is one of the main presenting symptoms and it is thought to be related to an inadequate secretion of ADH (SIADH). Since AIP is an uncommon disease, there is little information about how AIP related hyponatremia responds ...

About 10–15% of prolactinomas (P) are resistant to Dopamine agonists (DA). We analyzed retrospectively ten resistant prolactinomas (RP) treated at our center between 1995 and 2014, to identify useful variables to predict DA resistance and its different patterns (biochemical resistance (BR), morphological resistance (MR) or both). BR is defined as the failure to normalize prolactin (PRL) levels with ≥ 2 mg/week of cabergoline (C) for at least 3 months. MR is consider...

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

Introduction: MTC accounts for 5% of thyroid cancers and can occur sporadically or as part of the multiple endocrine neoplasia type 2 syndrome (MEN 2). The objective of our study is to evaluate the prognostic factors and outcomes of patients with MTC in the community setting.Methods: Retrospective descriptive multicenter study of patients with histological diagnosis of MTC. Descriptive, bivariate analyses (Student t for cuantitative and ...